In a 6-3 decision, the Supreme Court has stayed enforcement of the OSHA rule that mandated vaccines for workplaces with 100 or more employees. Justices Roberts, Thomas, Alito, Gorsuch, Kavanaugh and Barrett all signed the per-curiam order to stay the mandate, and Gorsuch wrote a concurrence that was also signed by Thomas and Alito.
You can read the decision here.
Based on a quick reading, it seems to me that the conservative bloc is willing to take a hard look at what is known as the major questions doctrine if this or a similar case makes its way to the Court. If that occurs, it will be a major blow to the administrative state.